They should. I've seen three Spider-Men fight together, they did well.

[Granted he saw fairly little of that fight, all things considered, and was not present for the parts where they did bad. But you know! Otto's generally got a lot of faith in them! And, honestly, just kinda thinks the idea is fun.]

Did you have a lot of "big team-up fights"? My universe was...well, it was very different. We didn't have a lot of super-people.